MYOFIBROBLASTS DERIVED TYPE V COLLAGEN PROMOTING TISSUE MECHANICAL STRESS AND FACILITATING METASTASIS AND THERAPY RESISTANCE OF LUNG ADENOCARCINOMA CELLS

Abstract Lung cancer is a leading cause of cancer-related mortality globally, with a dismal 5-year survival rate, particularly for Lung Adenocarcinoma (LUAD).Mechanical changes within the tumor microenvironment, such as extracellular matrix (ECM) remodeling and fibroblast activity, play pivotal roles in cancer progression and metastasis.However, th

Many patients with genetic syndromes have special facial features, which boast significant potential value for clinical diagnosis.Deep learning and computer vision technology can be employed to diagnose genetic diseases by analyzing facial features of patients.As a matter of fact, the application of deep learning technology in the area of genetic d

The colorful worldviews of our contemporaries are a manifestation of world-wide processes in the world, which are usually defined through the concepts of "globalization processes", "information day", "postmodern instruction" and are accompanied in particular by such negative additions as "global problems of humanity", "information gluttony" "," the

Gorontalo is one of the areas around Tomini bay which is the place used for fighting in the surrounding kingdoms (Ternate, Tidore, Palasa, Bugis, Hair Makassar), againts the Netherlands.In addition, the Gorontalo region was targeted by the Mindanao (Mangindano) and Galela pirates who controlled the waters of Tomini Bay.To deal with these attacks, t

Type 2 diabetes mellitus (T2DM) and Dishwasher Hinge Bush metabolic syndrome (MS)facilitate the development of ischemic cerebrovascular diseases.This article presents the results of examination of patients withischemic cerebrovascular diseases associated with T2DM andMS.We have found that T2DM adversely affects Safety Rollers the progressionof athe